A comprehensive European road safety research roadmap has been prepared within the framework of the EC co-funded support action PROS – Priorities for Road Safety Research in Europe. About 120 experts from more than 40 stakeholder organisations – with the active participation of NTUA – have contributed to the development of this roadmap within the two years of running time of the PROS support action. This Report contains a complete research topics list with their priorities together with a long-term road safety research roadmap. This roadmap is expected to be exploited by the European Commission, National Administrations, the Industry and the European Research Community in order to guide road safety research activities within the coming years.