The World Health Organization has released a Road Safety Manual for decision-makers and practitioners concerning Powered Two- and Three-Wheeler (PTW) Safety. This Manual describes the magnitude of PTW death and injury; key risk factors; ways of assessing the PTW safety situation in a given setting and preparing an action plan; and how to select, design, implement and evaluate effective interventions. The Manual also stresses the importance of a comprehensive, holistic approach that includes engineering, legislation and enforcement measures, as well as behavioural changes.