The Infrastructure Thematic Report of the E-Survey of Road Users’ Safety Attitudes (ESRA) has been published with the active contribution of NTUA, containing a wealth of information on road safety in 39 countries across Europe, America and Asia-Oceania, based on the ESRA3 survey. This Thematic ESRA3 Report describes the use and the safety perception of infrastructure among different road users, including car drivers, moped riders and motorcyclists, cyclists and pedestrians. The results revealed that car drivers in Europe have the highest usage of inter-city motorways, while America leads in using thoroughfares and high-speed roads within cities. Moreover, strong linear relationships were discovered between the perceived safety of road infrastructure and road fatality rates.