The European Commission together with 2Zero, ERTRAC, and CCAM co-organised with great success the 5th European Conference H2020RTR21, which was held in Brussels, on 29-30 March 2022. 65 H2020 projects presented their new discoveries and achievements, how they tackled hurdles and resolved challenges, and what are the next research steps in different important areas for road transport: Green Vehicles, Urban Mobility, Logistics, Intelligent Transport Systems, Safety, Automated Road Transport.