The European Commission with the active contribution of NTUA, SWOV and KFV has published at the European Road Safety Observatory, the Powered Two-Wheelers Thematic Report which refers to the safety of moped riders and motorcyclists as vulnerable road users. This Thematic Report highlights the key risks associated to PTWs traffic, in terms of rider characteristics and behaviour, road infrastructure, traffic patterns and safety culture. Moreover, a series of specific countermeasures regarding safer road users, vehicles and roads are suggested in view of minimising both crash risk and severity.