The European Commission with the active contribution of NTUA, SWOV, VIAS Institute and KFV has published at the European Road Safety Observatory, the Professional Drivers Thematic Report which mainly refers to the safety of heavy goods vehicles (HGVs) and buses. This Thematic Report highlights that the safety of HGVs and buses are significantly influenced by road infrastructure due to their unique characteristics such as mass, maneuverability, and acceleration/deceleration capabilities, as well as the fatigue and distraction of the drivers. Furthermore, countermeasures about separating these heavy vehicles from other road users, providing professional drivers with timely warnings about hazardous or restricted road sections and addressing the need for adequate and well-managed overnight parking facilities for HGVs are suggested.