The International Road Federation (IRF) published recently the Connected and Autonomous Mobility Manifesto, with the active contribution of NTUA. The main objective of this Manifesto is to provide the basis for discussion to proactively prepare ourselves for the revolution that Connected and Autonomous Vehicles (CAV) bring to the mobility and transport sector. The Manifesto summarises the initial discussions about the key challenges of the main workstreams guiding the IRF Connected and Autonomous Mobility Committee (CAMC) work, including the regulatory framework, technological innovations, future developments and social needs.