A paper titled “The European road safety decision support system on risks and measures” authored by the Horizons 2020 SafetyCube project team is now published in Accident Analysis and Prevention. The European Road Safety Decision Support System is an innovative system providing the available evidence on a broad range of road risks and possible countermeasures. This paper describes the scientific basis of the DSS. The structure underlying the DSS consists of (1) a taxonomy identifying risk factors and measures and linking them to each other, (2) a repository of studies, and (3) synopses summarizing the effects estimated in the literature for each risk factor and measure, and (4) an economic efficiency evaluation instrument (E3-calculator).