The World Health Organization has released a Road Safety Manual for decision-makers and practitioners concerning Powered two- and three-wheeler Safety. Key risk factors for motorcycle traffic injuries include the non-use of helmets, vehicle speed, alcohol use, mixed traffic conditions, a lack of protection from the vehicle in a crash and a lack of safe infrastructure for PTWs such as poor road surfaces and roadside hazards. This second edition of the Powered two- and three- wheeler Safety Manual includes guidelines for implementing, enforcing and evaluating 2-and-3-wheeler safety programmes.